Greener Journal of Biological Sciences

Excellence and Timeliness


Choose Language

Greener Journal of  Biological Sciences Vol. 3 (7), pp. 276-281, September 2013.

 © 2013 Authors

Research Paper

Manuscript Number: 082613804


Hepatitis B Envelope Antigen (HBeAg) Antiginemia and the Development of Hepatocellular Diseases (HCDs): A Case Study of Kano-Nigeria


1D. W. Taura, *2A. Hassan, 2M. Dahiru, 3A. M. Yayo and

3H. Takalmawa


    1Department, of Microbiology Bayero University, P.M.B. 3011, Kano – Nigeria.

    2Department of Biological Sciences, Federal University, Kashere, P.M.B. 0182,

Gombe – Nigeria.

        3Department of Medical Microbiology/ Parasitology, Faculty of Medicine, Bayero University, Kano-Nigeria.


1Email: dalhawt @


*Corresponding Author’s Email:  auwal_hssn @


The presence of hepatitis B envelope antigen (HBeAg) in serum indicates active viral replication in the Hepatocyte. HBeAg is thus a surrogate marker for the presence of hepatitis B virus (HBV). To determine the relationship between the positivity for HBsAg, HBeAg and development of hepatocellular diseases (HCDs). Two hundred (200) blood samples each of which were HBsAg-seropositive amongst patients attending Aminu Kano teaching hospital Kano, Nigeria, between April and November 2012, were tested for HBeAg using HBV combo kits (Cortez diagnostics). The status of HCDs was ascertained by some specific liver enzyme tests, which include alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP). The results of the study involved the screening of 200 sero-positives patients to HBsAg, out of which 34 (17.0%) were sero-positive to HBeAg. The relative risk of infection was found to be higher in males 31(15.5%) than in females 3(1.5%) for the surrogate marker. The most susceptible age group for HBeAg infection (6.0%) was found to be higher in the bracket ≤20 years. The occurrence of active, ongoing liver disease, indicated by the presence of HBeAg was significantly higher among males (P≤0.05). Analysis of the liver enzymes activity showed elevated serum level of ALT in 28(44.8%) of the HBeAg infected subjects indicating ongoing liver damage with 6(5%) perhaps developed hepatocellular diseases in relation to HBeAg. The percentage prevalence rate of HBeAg was higher in males than females and there was strong association between the positivity for HBeAg and the development of HCDs.

Keywords: Hepatitis, antigen, liver, hepatocellular, diseases, serum, blood.

Return to Content         View Reprint (PDF) (210KB)

Call for Papers/Books

Call for Scholarly Articles

Authors from around the world are invited to send scholary articles that suits the scope of this journal. The journal is currently open to submissions and will process and publish articles promptly.

The journal is centered on quality and goes about its processes in a very timely fashion. Seasoned editors/reviewers will be consulted to review each article(s), profer quality evaluations and polish the articles with expertise before publication.

Simply send your article(s) as an e-mail attachment to or



Login Form

Other Journals