Greener Journal of Biological Sciences

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Greener Journal of  Biological Sciences Vol. 3 (8), pp. 319-324, October 2013.

 © 2013 Authors

Research Paper

Manuscript Number: 060913819



Histopathological changes in Spleen caused by Pseudomonas aeruginosa DNA



Abed Hassan Baraaj and

*Harith Jabbar Fahad Al-Mathkhury




Department of Biology, College of Science, University of Baghdad, Baghdad 10071, Iraq.


*Corresponding Author’s Email: harithfahad @, Mobile; 00964 7712277025


Upon its release due to cell lysis, bacterial DNA has the ability to stimulate the immune system causing serious damage in tissue. Intraperitoneally injection of P. aeruginosa DNA in rats caused several histopathological changes in the splenic tissue included; a marked germinal center hyperplasia in the white pulp which results in the increase of follicles number within germinal center. Furthermore, apoptotic debris engulfed by macrophages in the marginal zone was noticed. Hemosiderin and degenerated cells were observed as well. In a conclusion, even though the bacterial cells are dead, their remains, especially DNA can cause damage to tissue.


Keywords: spleen, Pseudomonas aeruginosa, DNA.

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