Greener Journal of Biological Sciences

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Greener Journal of  Biological Sciences Vol. 3 (9), pp. 325-329, November 2013.

 © 2011 Greener Journals

Research Paper

Manuscript Number: 280913872

 

OprD Expression and Imipenem Resistance in Pseudomonas aeruginosa

 

 

Hadeel Kareem Musafer1 and

Harith Jabbar Fahad Al-Mathkhury*2

Majeed Arsheed Sabbah3

 

 

1Department of Biology, College of Science, University of Mustansiriyah, Baghdad, Iraq.

2Department of Biology, College of Science, University of Baghdad, Baghdad, 10071 Iraq.

3Biotechnology Research Centre, Al-Nahrain University, Baghdad, Iraq.

 

 

*Corresponding Author’s Email: harithfahad @ scbaghdad.edu.iq, Mobile: 00964 7712277025


Abstract:

Pseudomonas aeruginosa is an opportunistic pathogen that produces highly resistant to antibiotic treatment. Here we show a presence of correlation between oprD expression and imipenem resistance. Minimal inhibitory concentration (MIC) for planktonic cells of P. aeruginosa was measured using E test. The results revealed the presence of oprD expression in 10 strains of P. aeruginosa isolates from patients with cystic fibrosis in order to evaluate their impact on imipenem susceptibility profiles. We investigated the relation between oprDgene expression and imipenem susceptibility profile showed isolates. Surprisingly, the imipenem-susceptible (P8) has low oprD expression that appeared in imipenem-susceptible,indicated a correlation of other mechanisms. This work forms a basis for future studies revealing the mechanisms of imipenem resistance in P. aeruginosa.

 

Keywords: Imipenem, oprDPseudomonas aeruginosa.


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