Greener Journal of Biological Sciences Vol. 4 (3), pp. 086-091, April 2014.
© 2011 Greener Journals
Manuscript Number: 012114052
Early Detection of T1DM Using Anti- GAD and Anti-Insulin Antibodies
Reem M. Obaid1*, Sabah N. Alwachi2, Munthir Mustafa3
1MSc in Endocrinology, Biology Department, College of Science, University of Baghdad. Baghdad-Al-Jadiria, Iraq.
2Prof of Endocrinology, Head of the Biology Department, College of Science, University of Baghdad. Baghdad-Al-Jadiria, Iraq.
3Ph.D. in Endocrinology, Ministry of Health.
*Corresponding Author’s Email: reem_m2478 @ yahoo. com, Mobile: 009647902553814
Markers have been described in type1 diabetes, a number of specific and non- specific antigens have been identified. The major auto-antigens involved in the destructive process of beta-cells leading to the development of type 1 diabetes are insulin hormone and glutamic acid decarboxylase (GAD).
This study was conducted to find the relationship between antibodies for this antigens and T1DM which can be used for the early detection of T1DM in normal Iraqi patients. The study was carried out on 80 samples (50 men and 30 women) with age ranged from (20– 60 years old), they are divided into three groups: Group 1 which have fasting plasma glucose (FPG) above 180 mg / dL. Group 2 which have FPG ranged from 120 – 180 mg/dL. Group 3 which have FPG below 120 mg /dL. The statistical analysis results showed no significant difference in the presence of antibodies between men and women. Significant (p<0.05) elevation in the level of (anti - insulin) in T1DM patients compared with control group. No significant elevation in the level of (anti- GAD). The results also showed that no positive results for (anti - insulin) present in the control group. One positive result for anti–
GAD present in the control group.
Keywords: T1DM, anti-GAD, anti-insulin.