Greener Journal of Biological Sciences

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Greener Journal of  Biological Sciences Vol. 6 (3), pp. 042-045, June 2016.

 © 2015 Authors

Research Paper

Manuscript Number: 040916074



Hypolipidaemic and Hypoglycaemic Effects of Aqueous Extracts of Vernoniaamygdalina (Bitter Leaf) on the Blood of Caviaporcellus (Guinea Pig)


*2Zitte Leelee Famii, 1Azubuine Justin Chinemerem and

1Wabali C Victor


1Department of Animal and Environmental Biology, Faculty of  Biological Science, College of Natural and Applied Science,  University of Port Harcourt, P.M.B 5323,  Port Harcourt, Nigeria.

*2Department of Crop/ Soil Science Faculty of Agriculture, university of Port Harcourt P.M.B. 5323 Choba,

Port Harcourt, Nigeria.


This study investigates the effects of aqueous extract of the leaves of Vernoniaamygdalina (Bitter leaves) on   blood glucose level and lipid profiles of normoglycaemic and normolipidaemic guinea pigs. The animals whose weights ranged between 350-500g (400g) were placed in four groups labelled groups A-C . They respectively received 375mg/kg/day, 750mg/kg/day and 1125mg/kg/day of V. amygdalina aqueous extract   for two weeks while group D served as the control. The animals were tested for their glucose level at two days interval while the lipid profile was estimated after the animals were humanely sacrificed at the end of two weeks treatment. The extract was found to evince significant difference in the treatment over the control at (P< 0.05) and a progressive time and dose dependent reduction of blood glucose concentration was observed. Similarly, the extract caused a significant reduction in   total cholesterol (TC), low density lipoprotein   (LDL) and triglyceride (TG) levels in the treatment groups at (P< 0.05). The increase in high density lipoprotein (HDL) was also found to be significant (P< 0.05) with respect to the control. This study therefore indicates that Vernoniaamygdalina aqueous extract will be effective in the control of blood glucose and lipids level in normoglycaemic and normolipidaemic individuals.


Keywords: Vernoniaamygdalina Caviaporcellus,  hypolipidaemic hypoglycaemic.

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