Greener Journal of Biological Sciences Vol. 6 (3), pp. 042-045, June 2016.
© 2015 Authors
Manuscript Number: 040916074
Hypolipidaemic and Hypoglycaemic Effects of Aqueous Extracts of Vernoniaamygdalina (Bitter Leaf) on the Blood of Caviaporcellus (Guinea Pig)
*2Zitte Leelee Famii, 1Azubuine Justin Chinemerem and
1Wabali C Victor
1Department of Animal and Environmental Biology, Faculty of Biological Science, College of Natural and Applied Science, University of Port Harcourt, P.M.B 5323, Port Harcourt, Nigeria.
*2Department of Crop/ Soil Science Faculty of Agriculture, university of Port Harcourt P.M.B. 5323 Choba,
Port Harcourt, Nigeria.
This study investigates the effects of aqueous extract of the leaves of Vernoniaamygdalina (Bitter leaves) on blood glucose level and lipid profiles of normoglycaemic and normolipidaemic guinea pigs. The animals whose weights ranged between 350-500g (400g) were placed in four groups labelled groups A-C . They respectively received 375mg/kg/day, 750mg/kg/day and 1125mg/kg/day of V. amygdalina aqueous extract for two weeks while group D served as the control. The animals were tested for their glucose level at two days interval while the lipid profile was estimated after the animals were humanely sacrificed at the end of two weeks treatment. The extract was found to evince significant difference in the treatment over the control at (P< 0.05) and a progressive time and dose dependent reduction of blood glucose concentration was observed. Similarly, the extract caused a significant reduction in total cholesterol (TC), low density lipoprotein (LDL) and triglyceride (TG) levels in the treatment groups at (P< 0.05). The increase in high density lipoprotein (HDL) was also found to be significant (P< 0.05) with respect to the control. This study therefore indicates that Vernoniaamygdalina aqueous extract will be effective in the control of blood glucose and lipids level in normoglycaemic and normolipidaemic individuals.
Keywords: Vernoniaamygdalina Caviaporcellus, hypolipidaemic hypoglycaemic.
Abosi, A. O. and Raseroka, B. H. (2003).In vivo anti-malarial activity of Vernoniaamygdalina.Br. J. Biomedical Sci. 60: 89 -91.
Adaramoye O., Akintayo O., Achem J. and Fafunsoo M. A. (2008). Lipid lowering effects of methanolic extract of Vernoniaamygdalinaleaves in rats fed on high cholesterol diet. Vascular Health and Risk Management, 4:235-241.
Akah P. A., Njoku O., Nwanguma A. and Akunyili D. (2004). Effects of aqueous leaf extract of Vernoniaamygdalinaon blood glucose and triglyceride levels of Alloxan-induced Diabetic rats (Rattusrattus). Animal Res. Int. 1(2):90-94.
Ekpo A., Eseyin O. A., Ikpeme A. O. and Edoho E. J. (2007).Studies on some biochemical effects of Vernoniaamygdalina in rats.As. J. Biochem.,2: 193-197.
Ijeh I. I., Igwe K. K. and Ejike E. C. (2008).Effects of leaf aqueous extracts of Vernoniaamygdalina Del on contraction of mammary gland and uterus of Guinea pigs Dams.Ame.Journ.Of Trop. Med. & Pub.Health. 1(3): 107-116.
Iwalokun, B. A. (2008). Enhanced antimalarial effects of chloroquine by aqueous Vernoniaamygdalina leaf extract in mice infected with chloroquine resistant and sensitive Plasodiumbergheistrains. African Health Sciences 8: 25-35.
Oruambo I. F., Onuba E. O. and Anyim S. D. (2010). Glucose tolerance test in hyperglycemic Guinea pigs treated with aqueous Vernoniaamygdalina.Medical Journ.Of Isl. World Acad.Of Sci.18:1, 21-26.
Osinubi A. A. (2005). Effects of Vernoniaamygdalinaand Chlorpropamide on blood glucose. Med. Journ. Of Isl. World Acad.Of Sci. 3, 115-119.
Toth, Peter (2005). "The "Good Cholesterol" High-Density Lipoprotein" Circulation111 (5): e89-e91. Retrieved 2 June 2011.
Ugwu C. E., Olajide J. E., Alumana E. O. and Ezeanyika L. U. (2011). Comparative effects of the leaves of Vernoniaamygdalina and Telfairiaoccidentalis incorporated diets on the lipid profile of rats.Afri.Journ.Of Biochem. Res.5(1), Pp. 28-32.
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