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Greener Journal of  Biological Sciences Vol. 7 (4), pp. 034-044, July 2017.

 © 2017 Greener Journals

Research Articles

Manuscript Number: 071617087


(DOI: http://doi.org/10.15580/GJBS.2017.4.071617087)

 

In-Vivo Screening of Antiplasmodial Activity of Methanolic Leaf Extract of Albizia chevalieri against Plasmodium Berghei Model

 

Hajara Sani Labaran 1*,  Samaila A.B. 1, Umar A.F. 1

 Nayaya A.J. 1, Danladi Muhammed Umar 2, Musa Muktar3, AbdulWahab Aliyu 4   and Nazeef Idris Usman5

 

1 Department of Biological sciences, Abubakar Tafawa Balewa university Bauchi, Bauchi state Nigeria.

2 Department of Biological sciences, Gombe State University

3 Biochemistry Department, Gombe State University.

4 Pharmacy Department  Gombe  State University

5 Bauchi  State University Gadau


Abstract


The need for new compounds active against malaria parasites is made more urgent by the rapid spread of drug-resistance to available anti-malaria drugs. The crude methanolic extract of Albizia chevalieri leaves was investigated for its anti-malarial activity against Plasmodium berghei (NK65) during early and established infections. The level of parasitaemia, mean survival time and weight variation of rats were used to determine the antimalarial activity of the extract. The Phytochemical screening of the crude extract were evaluated to elucidate the possibilities of its antimalarial effects. The safety of the extract was also investigated in rats of both sexes by the acute oral toxicity limit test. The leaf extract demonstrated significant (P<0.01) dose dependent activity against the parasite in the suppressive and curative, and also had repository activity. The antimalarial effect of A.chevalieri is comparable to that of artermether. The leaf extract also prolonged the survival time of the infected rats. The LD50 of the plant extract was established to be >3000mg/kg body weight in rats. The results showed that the leaf extract of the plant has potential antiplasmodial activity, which can be exploited in malaria therapy. Accordingly with further studies, this plant could serve as a potential source of new and novel antimalarial drug for the control of malaria 


Keywords: A. Chevalieri, Plasmodium Berghei, parasitaemia, suppression


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