Zige et al
Greener Journal of Microbiology and Antimicrobials Vol. 1 (2), pp. 016-019, December 2013.
ISSN: 2354-2284 © 2013 Greener Journals
Manuscript Number: 110713950
Antibacterial Activity of Ethanol, Crude and Water Extract of Chromolaena OdorataLeaves on S Typhi and E Coli
*Douye V. Zige1, Elijah I. Ohimain1 and
Medubari B. Nodu2
1Pharmaceutical Microbiology Research Unit Department of Biological Sciences, Niger Delta University, Wilberforce Island, Bayelsa State Nigeria.
2Department of Animal Science, Niger Delta University Wilberforce Island, Bayelsa State Nigeria.
*Corresponding Author’s Email: douyecool2000 @ gmail.com, Mobile Number: 08063588014
Antimicrobials from plant have enormous therapeutic potentials which have been established a long time ago. The leaves of Chromolaena odarata (commonly called Siam weed), which is an ancient remedy for the treatment of wounds and many ailments was tested for its antimicrobial activities on S Typhi and Escherichia coli. The agar pour plate method was used to test for its antimicrobial activity on the test isolate, the extracts of Chromolaena odorata was introduced directly into the wells of the two tested organism. Laboratory study shows that Chromolaena odorata has antimicrobial action against these organisms. However, result after a 72hr incubation showed that ethanol extract had the highest zone of inhibition for S Typhi (37.7mm) and water extract on E coli (32.3mm) and also mean value of leaf extracts of Chromolaena odarata were found to exhibit a significant antibacterial activity against S Typhi as compared to E coli, revealing that the extract of Chromolaena odarata is more effective on S. Typhi than E coli. This research work establishes a good support to the use of these plants in herbal Remedies and as base for development of new drugs against typhoid fever and E coli related diseases.
Keywords: Antimicrobials, Chromolaena odorata, Drug discovery, E coli, Medicinal plant, Salmonella Typhi.