Douye et al
Greener Journal of Microbiology and Antimicrobials Vol. 2 (2), pp. 026-031, May 2014.
ISSN: 2354-2284 © 2013 Greener Journals
Manuscript Number: 111813971
Antimicrobial Activity of Ethanol Extract ofSenna Alata Leaves against Some Selected Microorganism in Bayelsa State, Nigeria
*Douye V. Zige1, Elijah I. Ohimain1 and
1Pharmaceutical Microbiology Research Unit, Department of Biological Sciences,
Niger Delta University, Wilberforce Island, Bayelsa State, Nigeria.
2Department of Medical Laboratory Science, Faculty of Allied Medical Sciences,
University of Calabar, Cross River State, Nigeria.
*Corresponding Author’s Email: douyecool2000 @ gmail. com,
Mobile number: +2348063588014
Senna alata is an underutilized shrub growing in many parts of the world and is known for its traditional use in the treatment of dermotophytes and other related ailment. The ethanol extract of Senna alata leaves was evaluated against some dermotophytes (Malassezia pachydermatis, Malassezia furfure, and Malassezia restricta, Malassezia globosa) and gastrointestinal bacterial pathogens (Salmonella Typhi, Escherichia coli,Proteus mirabilis, Pseudomonas auriginosa, Klebsiella spp). The extract was tested using well diffusion technique against pathogens and found effective against the selected pathogens. The highest zone of inhibition was observed against Klebsiella spp (27.4mm), followed by S. Typhi (26mm) and P. auriginosa (26mm), P. mirabilis(21.7mm) and E. coli (19.5mm). In case of fungi, it was most effective against M. globosa (19.7mm) and M. pachydermatis (17mm). It was not effective against M. furfure and M. restricta. Thus, S. alata is a good antimicrobial agent against bacterial and fungal pathogens of humans.
Keywords: Antifungal, Antibacterial, Chemotherapy, dermotophyte, Ethanol Extract,Senna alata.