Taiwo et al
Greener Journal of Medical Sciences Vol. 2 (6), pp. 146-151, December 2012
ISSN: 2276-7797 © 2011 Greener Journals
Manuscript Number: 110312210
Evaluation of Haemorheological Parameters in Cigarette Smokers in Western Nigeria
Oke, Olusegun Taiwo1, Ndem Benedict Nsa2, Oyedeji Samuel Oyewole1, Akanni Olufemi3 Adedire Olusoji Aderemi1
1School of Medical Laboratory Science, Obafemi Awolowo University Teaching Hospital Complex, P.M.B.5538 Ile-Ife, Osun State Nigeria.
2Department of Medical Laboratory Science University of Calabar, Cross-River state, Nigeria.
3Biomedical Science Department, Ladoke Akintola University of Technology, Osogbo, Osun State Nigeria.
Corresponding Author’s Email: oketaiwo @ yahoo.com, Phone +2348033772582
Tobacco use is widely spread throughout the world, from countries with low income economics to the most influential industrialized nations. The effect of smoking on human health are serious and in many cases, deadly. This study aimed at estimating the haemorheological parameters and examining the effects of this social behavior on them with a view to educate the smokers and the society. This study was carried out among the regular smokers that smoke not less than two sticks of cigarettes per day. Ninety (90) subjects were studied, comprising of sixty (60) smokers subjects, willingly volunteered to participate in the study and thirty (30) nonsmoker subjects that served as control for the study. The haemorheological parameters determined were packed cell volume (PCV), Erythrocyte sedimentation rate (ESR), Fibrinogen concentration (FIBC), Whole blood viscosity (WBV) and Plasma viscosity (PV). It was observed that there were statistically significant difference in WBC, ESR, FIB, and PCV (p<0.05, p<0.01, p<0.01 and p<0.05). Though experimental differences were noticed in PLT, WBV and PCV when the results of smokers were compared with the non smokers, the values were not statistically significant (p>0.05). In the correlation results, WBC correlate negatively with PLT and PV (r=-0.142, r=-0.042), PLT correlate negatively with ESR and PCV (r=-0.124, r=-0.172), and ESR correlate negatively with WBV(r=-0.065). The correlation between FIBC and WBV, PV, (r=-0.304, r=-0.077), WBV and PV(r=-0.333) were negative and all these were not statistically significant (p>0.05). The negative correlation that exist between the PV and PCV(r=-0.846) was statistically significant (<0.01). The positive correlation noticed and statistically significant were between WBC and ESR (r=0.341) (<0.05), also between PLT and FIBC (r=0.477) (<0.01).
Conclusion: Smoking exerts negative influence on the haemorheological parameters and these are the contributing factors that lead to cardiovascular and atherosclerosis that usually occur in cigarette smokers and cause of their death. Also smokers are more prone to infection more than nonsmokers because of their low level of immunity.
Key Words: haemorheological, Fibrinogen, Platelets, White blood cells, Whole blood viscosity, Plasma viscosity.