Sodipo et al
Greener Journal of Medical Sciences Vol.3 (1), pp. 008-017, January 2013
ISSN: 2276-7797 © 2011 Greener Journals
Comparative Assessment of the Total Lipid Profile, Faecal Cholesterol, Very Low Density Lipoprotein Cholesterol (VLDL-C) and Altherogenic Index (A.I.) of the Aqueous Fruit Extract of Solanum macrocarpum, α-solanidine and Antihyperlipidaemic Drugs on
Triton-Induced Hyperlipdaemic Rats
O.A. Sodipo*1, F. I. Abdulrahman2, U.K. Sandabe3, and
*1Department of Clinical Pharmacology and Therapeutics, College of Medical Sciences, University of Maiduguri P.M.B. 1069, Maiduguri.
2Department of Chemistry, Faculty of Science, University of Maiduguri.
3,4Department Veterinary Physiology, Pharmacology and Biochemistry, Faculty of Veterinary Medicine,
PMB 1069, Maiduguri.
1*Corresponding Author’s Email: sodipoolufunke @ yahoo.com,
Studies were undertaken on the effect of 50mg/kg each of the aqueous fruit extract of Solanum macrocarpum, α-solanidine, (a steroidal glycoalkaloid found in the Solanaceae), three antihyperlipidaemic drugs namely nicotinic acid, simvastatin and cholestyramine) on forty two (42) rats made hyperlipidaemic by treating them with 400 mg/kg triton-X for 7 days. The rats were divided into 7 groups of 6 rats each. At 24hrs, 48hrs and 72hrs respectively, the rats in each group were humanely sacrificed and blood samples collected for analysis of total lipid profile [total cholesterol, triglyceride, high density lipoprotein-cholesterol (LDL-C) and low density lipoprotein cholesterol (LDL-C)]. Very low density lipoprotein cholesterol (VLDL-C) and atherogenic index (A.I.) were also calculated. Faecal samples were also collected, homogenized and extracted with chloroform/methanol in the ration 2:1 for faecal cholesterol determination. The extract, α-solanidine and the three hypolipidaemic drugs all significantly decreased (P<0.05) LDL-C and triglycerides at 48hrs and 72hrs, whilst HDL-C increased significantly (0.05) throughout the period of study (24hrs, 48hrs and 72hrs). There was no change in total cholesterol (P>0.05) for all the five substances tested throughout the period of study, whilst VLDL-C and A.I. decreased significantly (P<0.05) at 24hrs, 48hrs and 72hrs. These results imply that under the condition of this study, the aqueous fruit extract of S. macrocarpum compared favourably with α-solanidine and the three hypolipidaemic drugs in reducing the risk of development of heart diseases.
Key words: Solanum macrocarpum, faecal cholesterol, total lipid profile, VLDL-Cholesterol, atherogenic index, α-solanidine, hyperlipidaemic rats, hypolipidaemic drugs.