Atiba et al
Greener Journal of Medical Sciences Vol. 3 (5), pp. 174-178, July 2013.
Manuscript Number: 011313373
Liver Enzymes and Lipid Profile Among Type 2 Diabetic Patients in Osogbo, Nigeria
1*Adeniran Samuel Atiba, 2Dolapo Pius Oparinde,
3Oluwole Adeyemi Babatunde, 4Temitope Adeola ‘Niran-Atiba,
5Ahmed K Jimoh, 6A A Adepeju
1*Department of Chemical Pathology, Ekiti State University Teaching Hospital, Ado-Ekiti, Ekiti State, Nigeria
2Department of Chemical Pathology, Ladoke Akintola University of Technology, Osogbo, Osun State, Nigeria
3Department of Community Medicine, Federal Medical Center, Ido-Ekiti, Nigeria
4Department of Biomedical Science, Ladoke Akintola University of Technology, Osogbo, Osun State, Nigeria
5Department of Chemical Pathology, Federal Medical Centre, Ido-Ekiti, Ekiti State, Nigeria
6Department of Biomedical Science, Ladoke Akintola University of Technology, Osogbo, Osun State, Nigeria
1*Corresponding author e-mail: atiadesam08 @ yahoo. com Mobile numbers: +2347030454127
Background: Type 2 DM has been linked with dyslipideamia and elevation of some liver enzymes, in fact it has been identified as independent risk factor for development of coronary artery disease (CHD). The risk of coronary heart disease in patients with type 2 DM with hepatic involvement was assessed in this study.
Method: A total number of 106 type 2 DM subjects with fasting plasma glucose greater than 7mmol/l with associated symptoms of DM, and another 60 aged and BMI matched controls with normal FPG (2.5-5.5mmol/l). The blood levels of Total Cholesterol, HDL-Cholesterol, LDL-Cholesterol, TG, AST, ALT, ALP and the fasting plasma glucose (FPG) were determined. Body mass index (BMI) was also calculated from the weight and height. Data analysis was done using SPSS (Version 15) Software. Variables were compared between DM subjects and controls, with statistical significance at p ≤0.05.
Results: LDL and TC were significantly lower in control than the subject group (2.35±1.15vs 3.09±1.26mmol/l; p<0.05) and (3.98 ±1.24 vs 4.41±1.39mmol/l p< 0.05) respectively. HDL/TC ratio was significantly higher in control than the subjects (0.28±0.13 vs 0.21±0.13mmol/l; p<0.05). Serum level of liver enzymes ALT, AST and ALP analyzed were significantly elevated in subjects than in the control group (12.69±6.75 vs 4.95±2.66 IU/L; p<0.05), (16.96±10.80 vs 7.83 IU/L±3.94; p<0.05) and (70.19±28.78 vs 23±8.77 IU/L; p<0.05) respectively.
A weak positive significant correlation between FPG and AST (r=0.268, p<0.05), TC and ALP (r=0.273, p<0.05), LDL and ALP (r=0.301, p<0.05) was observed. However a weak negative significant correlation exist between HDL/TC and ALP (r=0.201, p<0.05).
Conclusion: There are evidences of dyslipidaemia and elevated liver enzymes in type 2 DM patients seen in Osogbo, Nigeria.
Keywords: liver enzymes, cardiovascular risk, type 2 DM, dyslipidaemia, body mass index.
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