Onubeze and Oguwike
Greener Journal of Medical Sciences Vol. 6 (2), pp. 030-035, May 2016.
ISSN: 2276-7797 © 2015 Greener Journals
Manuscript Number: 041316077
Evaluation of Activities of Aquoepus Extract of M Avocado (Persea americana) on Wound Healing and Biochemical Indices of Albino Wistar Rats
Onubeze DPM1 and Oguwike FN2*
1Department of Community Medicine, Anambra State University Teaching Hospital Amaku Awka, Nigeria.
2Department of Physiology, Faculty of Basic Medical Sciences Anambra State University Uli, Nigeria.
The aqueous crude extracts of some plants could play a helpful role in hastening the coagulation system in a damaged tissue or vessels at the same time restore order in a diseased tissue, hence this research evaluated the activities of aqueous crude extract of Avocado (Persae Americana) on wound healing and biochemical profile of male albino wistar rats using Sixty rats. The animals weighing 180-200g were randomly selected and placed into five (5) groups group A (control), group B (Skin ulcered rats on extract), group C (rats with skin ulcers on normal saline), group D (wound incised animals on extract) and group E(incised rats on normal saline). All the test rats were 12 animals in each group. They were gavaged with 1ml of aqueous extracts of Avocado for twenty eight days (acute study) before blood samples were collected from them for investigations.
The results showed that avocado extract decreased haemoglobin concentration, Packed cell volume and White blood cell (p<0.05).It has no effect on platelet counts (p>0.05), it shortened days of healing in rats inflicted with wounds and those with skin ulcers. The bleeding and clotting times were reduced as well as the cholesterol level (p<0.05), again the LD50 of Avocado is zero in albino wistar rats.
It can be deduced from the study that Avocado (Persae Americana) possess some active principles that hastens wound healing and reduces cholesterol level.
Key words: Wound healing, avocado, bleeding time, clotting time, cholesterol hemoglobin.
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