aim of the present work is the evaluation of anti cancer
aerial parts extracts
and also the investigation of the phytoconstituents from the
extractsof the plant.Petroleum ether (40-60оC),
Chloroform, ethyl acetate and methanol 80% extracts ofC.
were tested for their anti cancer activity on three cancer
(renal), UACC62 (melanoma) and MCF7 (breast) cancer cells
using a Sulforhodamine B (SRB) assay.
Petroleum ether of C. papaya
at the concentration of 100 µg/ml
has shown a significant anticancer effect for MCF7 (breast)
cancer cells and
showed less anticancer effect for the other two cancer cells
while the other extracts have mild anticancer effect on the
three cancer cells. Phytochemical profile of the plant
extracts proves the presence of flavonoids, tannins,
alkaloids, carbohydrates and triterpenes and bioactive
fractionation of petroleum ether extract revealed the
isolation and identification of β-sitosterol, stigmasterol
as the major constituents.
The results suggest that
petroleum ether extract ofC. papaya
exhibited a significant anti cancer activity for breast