Greener Journal of Medical Sciences

Greener Journal of  Medical Sciences Vol. 5 (3), pp. 043-047, June 2015.

 ISSN: 2276-7797 

Research Paper

Manuscript Number: 030815041

(DOI http://doi.org/10.15580/GJMS.2015.3.030815041)

 

Renal function of post neonatal tetanus cases as seen in University of Port Harcourt Teaching Hospital

 

*¹Yaguo Ide Lucy Eberechukwu, ²Agi Chukwuemeka Emmanuel, ³Uchenwa-Onyenegecha Tochi Ada

 

¹Department of Paediatrics and Child Health, University of Port Harcourt Teaching Hospital.   Port Harcourt, Rivers State, Nigeria, West Africa P.M.B 6173. E-mail: lucyaguolucy@gmail.com,

²Department of Radiology, University of Port Harcourt Teaching Hospital. Port Harcourt, Rivers State, Nigeria, West Africa P.M.B 6173^. E-mail: achukwuemeka@hotmail.com

³Department of Paediatrics and Child Health, University of Port Harcourt Teaching Hospital.   Port Harcourt, Rivers State, Nigeria, West Africa P.M.B 6173^.  E-mail: tochiuchenwa@yahoo.com

 

Corresponding Author’s Email: lucyaguolucy@gmail.com, phone: +2348109864336

Abstract

Background: Acute kidney injury (AKI) is a known complication of tetanus and contributes to morbidity and mortality  among children with tetanus. The aim of this study was to ascertain the renal functions in  patients with post neonatal  tetanus over a 4year peroid.

 

Methods: All cases of post neonatal tetanus admitted into the department of Paediatrics UPTH between October 2009 to April 2013 were recruited and studied. The renal function studies done included urinalysis, serum electrolytes, urea and creatinine, renal ultrasound scan and fluid input and output monitoring.

 

Results: 17 cases of post neonatal tetanus were studied. There were 9(53%) males and 8(47%) females giving a male female ratio of 1.1:1. The ages of the patients ranged from 2-16years with a mean age of 9.81±4.4years. Most cases were above 5years of age(13(76.5%). Of the 17 cases only 2(11.8%) were fully immunised. The mean laboratory values were: serum creatinine 55.8±4.9umol/L, urea 2.5±1.1mmol/L, sodium 132.8±3.3mmol/L, potassium 3.6±0.7mmol/L and bicarbonate 22.3±4.9mmol/L which were all within the normal range for our laboratory. The urinalysis and renal ultrasound findings were also normal. None of our patient had oliguria.

 

Conclusion: AKI as a complication of post neonatal tetanus is uncommon in paediatric patients.

 

Key words: Post neonatal tetanus, Children, Renal function.

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References

Adekanle O, Ayodeji OO, Olatunde LO (2009). Tetanus in a Rural Setting of South-Western Nigeria: a Ten-Year Retrospective Study. Libyan J Med  4: 78-80.

 

Akani NA, Nte AR, Oruamabo RS (2004). Neonatal tetanus in Nigeria: One social scourge too many! Nig J Paediatr  31: 1-9.

 

Alhaji MA, Akuhwa RT, Mustapha MG, Ashir GM, Mava Y, Elechi HA (2013). Post neonatal tetanus in University of Maiduguri Teaching Hospital, Northeastern Nigeria. Niger J Paed  40: 154-7.

 

Anah MU, Etuk IS, Ikpeme OE, Ntia HU, Ineji EO, Archibong RB (2008). Post Neonatal Tetanus in Calabr Nigeria: A 10 Year Review. Niger Med Pract  54: 45-7.

 

Bhatia R, Prabhakar S, Grover  VK (2002). Tetanus. Neurol India  50: 398-407.

 

Cook TM, Protheoze RT, Handel JM (2001). Tetanus: A review of literature. Br J Anaesth  87: 477-87.

 

Daher EF, Abdulkader RC, Motti E, Marcondes M, Sabbaga E, Burdmann EA (1997). Prospective study of tetanus- induced acute renal dysfunction. Role of adrenergic overactivity. Am J Trop Med Hyg  57: 610-4.

 

Gbadegesin RA, Adeyemo AA, Osinusi K (1996).  Childhood post neonatal tetanus. Nig J Paediatr  23: 11-5.  

 

Hilton AR (2006). Acute renal failure. BMJ  333: 786-90.

 

Kaur S, Mishra,D, Juneja M (2014). Acute renal failure in tetanus. Indian J Pediatr  81: 207.

 

Mallick IH, Winslet MC (2004). A review of the epidemiology, pathogenesis and management of tetanus. Int J Surg  2: 109-12.

 

Martinelli R, Matos CM, Rocha H (1993). Tetanus as a cause of acute renal failure: Possible role of rhabdomyolysis. Rev Soc Bras Med Trop  26: 1-4.

 

Moura Filho FR, Mendonca PR, Lima EB, Silva JS, Pinho ML, Mota RM et al (2008). Acute renal failure and other clinical features in tetanus patients from northeastern Brazil. Ann Trop Med Public Health  1: 52-5.

 

Ojini FI, Danesi MA (2005). Mortality of tetanus at the Lagos University Teaching Hospital, Nigeria. Trop Doct  35: 178-81.

 

Oruamabo RS. Neonatal Tetanus. In : Paediatrics and Child health in a Tropical Region. Azubuike JC, Nkanginieme KEO. eds 2nd edition. University of Port Harcourt Press. 2007;Pg 217.

 

Oyedeji OA, Fadero F, Joel-Madewase V, Elemile P, Oyedeji GA (2012). Trends in neonatal and post neonatal tetanus admissions at a Nigerian Teaching Hospital. J Infect Dev Ctries  6: 847-53.

 

Oyelami OA, Aladekomo TA, Ononye FO (1996).  A 10 year retrospective evaluation of cases of post neonatal tetanus seen in a paediatric unit of a university teaching hospital in south western Nigeria 1985 – 1994. Cent Afr J Med  42: 73-5. 

 

Pinder M (1997). Controversies in the management of severe tetanus. Intensive Care Med  14: 129-43.

 

Seydi M, Soumare M, Gbangba-Ngai E, Ngadeu JF, Diop BM, N'diaye B, et al (2005). Current aspects of pediatric and adult tetanus in Dakar. Med Mal Infect  35: 28-32.

 

WHO vaccine-preventable diseases: monitoring system.2014 global summary.[internet][updated 2014 Dec 5; cited 2015 Feb 10]. Available from http//www.apps.who.int/immunization-monitoring/globalsummary.

 

Wilkins CA, Richter MB, Hobbs WB, Whticomb M, Bergh N, Carstens J (1988). Occurrence of Clostridium tetani in soil and horses. S Afr Med J  73: 718-20.

 

Yaguo Ide LE, Nte AR (2011). Post neonatal tetanus: an apparently ‘neglected’ disease? HMRJ  9/10: 24-29.

 

Yaguo Ide LE, Nte AR (2012).  Neonatal and post neonatal tetanus in Nigeria: the time to act is now. HMRJ  11/12: 55-64.