Assessment of Hypogonadism in Men with Type 2 Diabetes Mellitus

Background: There is an established relationship between type 2 diabetes and Hypogonadism. Testosterone, the main gonadal steroid in men is lower in diabetic men when compared with healthy subjects. Currently, very few diabetic men with testosterone deficiency are diagnosed and treated worldwide. Knowledge of testosterone levels of patients will reveal those with androgen deficiency so that appropriate treatment will be offered. Objective: The aim of this study was to assess the prevalence of Hypogonadism based on biochemical measures of total testosterone deficiency in men with type 2 diabetes in Port Harcourt. Methods: Type 2 diabetic patients attending the Medical Out-Patient Clinic of University of Port Harcourt Teaching Hospital (UPTH) between April and May, 2012 were used for this study. Fasting blood sugar was measured using Randox kit, Testosterone was measured using Enzyme Linked Immunoassay. Data were analyzed using the SPSS package (Version 20.0.0). The mean levels of testosterone for the patients as a group and also according to age, glycemic state and duration of disease were computed. Values were expressed as a percentage of each group or as mean + 2SD. Comparisons between groups were made using the student t-test at 95% confidence interval. Results were significant if P < 0.05. Results: One hundred and forty two (142) patients were tested within the study period. 31.7% (45) of the 142 diabetic patients had a lower than normal testosterone level (Testosterone<3.0ng/ml). The mean testosterone levels decreased significantly in the older men (>70 years). The percentages of patients with low testosterone levels were increasingly higher as the age increased. 10.7% of patients aged 41-50 years had low testosterone levels. Their mean was 3.51+ 0.54 ng/ml. 12.8% of patients aged 51-60 years had low testosterone and their mean level was 3.35+0.58 ng/ml. 25.0% of the patients aged 61-70 years had low testosterone levels. Their mean was 2.89+0.68, while 92.3 of the patients >70 years had low testosterone with a mean of 1.57+0.70 ng/ml. The percentage of patients with low testosterone was not altered by the degree of rise in blood sugar level. 32.2% of the patients whose fasting blood glucose level were <10.0mmol/L had low testosterone levels and their mean was 2.99+0.83ng/ml while 28.0% of the patients with fasting blood glucose level >10mmol/L had low testosterone levels and their mean was 3.0+0.67 ng/ml. There was no significant difference between the two groups. 17.4% of the patients whose disease has lasted for 1-5 years had low testosterone level and their mean was 3.27+0.58 ng/ml while 74.1% of the patients with disease duration between 6-10 years had low testosterone levels and a mean of 2.23+0.78ng/ml. 83.3% of the patients with disease duration >10years had low testosterone levels and their mean level was 1.62+1.81ng/ml. Conclusion: Testosterone levels are low in type 2 diabetic men. These levels are further affected by age and duration of disease. Glycemic status had no statistically significant. Read more
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Assessment of Hypogonadism in Men with Type 2 Diabetes Mellitus

Background: There is an established relationship between type 2 diabetes and Hypogonadism. Testosterone, the main gonadal steroid in men is lower in diabetic men when compared with healthy subjects. Currently, very few diabetic men with testosterone deficiency are diagnosed and treated worldwide. Knowledge of testosterone levels of patients will reveal those with androgen deficiency so that appropriate treatment will be offered. Objective: The aim of this study was to assess the prevalence of Hypogonadism based on biochemical measures of total testosterone deficiency in men with type 2 diabetes in Port Harcourt. Methods: Type 2 diabetic patients attending the Medical Out-Patient Clinic of University of Port Harcourt Teaching Hospital (UPTH) between April and May, 2012 were used for this study. Fasting blood sugar was measured using Randox kit, Testosterone was measured using Enzyme Linked Immunoassay. Data were analyzed using the SPSS package (Version 20.0.0). The mean levels of testosterone for the patients as a group and also according to age, glycemic state and duration of disease were computed. Values were expressed as a percentage of each group or as mean + 2SD. Comparisons between groups were made using the student t-test at 95% confidence interval. Results were significant if P < 0.05. Results: One hundred and forty two (142) patients were tested within the study period. 31.7% (45) of the 142 diabetic patients had a lower than normal testosterone level (Testosterone<3.0ng/ml). The mean testosterone levels decreased significantly in the older men (>70 years). The percentages of patients with low testosterone levels were increasingly higher as the age increased. 10.7% of patients aged 41-50 years had low testosterone levels. Their mean was 3.51+ 0.54 ng/ml. 12.8% of patients aged 51-60 years had low testosterone and their mean level was 3.35+0.58 ng/ml. 25.0% of the patients aged 61-70 years had low testosterone levels. Their mean was 2.89+0.68, while 92.3 of the patients >70 years had low testosterone with a mean of 1.57+0.70 ng/ml. The percentage of patients with low testosterone was not altered by the degree of rise in blood sugar level. 32.2% of the patients whose fasting blood glucose level were <10.0mmol/L had low testosterone levels and their mean was 2.99+0.83ng/ml while 28.0% of the patients with fasting blood glucose level >10mmol/L had low testosterone levels and their mean was 3.0+0.67 ng/ml. There was no significant difference between the two groups. 17.4% of the patients whose disease has lasted for 1-5 years had low testosterone level and their mean was 3.27+0.58 ng/ml while 74.1% of the patients with disease duration between 6-10 years had low testosterone levels and a mean of 2.23+0.78ng/ml. 83.3% of the patients with disease duration >10years had low testosterone levels and their mean level was 1.62+1.81ng/ml. Conclusion: Testosterone levels are low in type 2 diabetic men. These levels are further affected by age and duration of disease. Glycemic status had no statistically significant. Read more
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Assessment of Hypogonadism in Men with Type 2 Diabetes Mellitus

Background: There is an established relationship between type 2 diabetes and Hypogonadism. Testosterone, the main gonadal steroid in men is lower in diabetic men when compared with healthy subjects. Currently, very few diabetic men with testosterone deficiency are diagnosed and treated worldwide. Knowledge of testosterone levels of patients will reveal those with androgen deficiency so that appropriate treatment will be offered. Objective: The aim of this study was to assess the prevalence of Hypogonadism based on biochemical measures of total testosterone deficiency in men with type 2 diabetes in Port Harcourt. Methods: Type 2 diabetic patients attending the Medical Out-Patient Clinic of University of Port Harcourt Teaching Hospital (UPTH) between April and May, 2012 were used for this study. Fasting blood sugar was measured using Randox kit, Testosterone was measured using Enzyme Linked Immunoassay. Data were analyzed using the SPSS package (Version 20.0.0). The mean levels of testosterone for the patients as a group and also according to age, glycemic state and duration of disease were computed. Values were expressed as a percentage of each group or as mean + 2SD. Comparisons between groups were made using the student t-test at 95% confidence interval. Results were significant if P < 0.05. Results: One hundred and forty two (142) patients were tested within the study period. 31.7% (45) of the 142 diabetic patients had a lower than normal testosterone level (Testosterone<3.0ng/ml). The mean testosterone levels decreased significantly in the older men (>70 years). The percentages of patients with low testosterone levels were increasingly higher as the age increased. 10.7% of patients aged 41-50 years had low testosterone levels. Their mean was 3.51+ 0.54 ng/ml. 12.8% of patients aged 51-60 years had low testosterone and their mean level was 3.35+0.58 ng/ml. 25.0% of the patients aged 61-70 years had low testosterone levels. Their mean was 2.89+0.68, while 92.3 of the patients >70 years had low testosterone with a mean of 1.57+0.70 ng/ml. The percentage of patients with low testosterone was not altered by the degree of rise in blood sugar level. 32.2% of the patients whose fasting blood glucose level were <10.0mmol/L had low testosterone levels and their mean was 2.99+0.83ng/ml while 28.0% of the patients with fasting blood glucose level >10mmol/L had low testosterone levels and their mean was 3.0+0.67 ng/ml. There was no significant difference between the two groups. 17.4% of the patients whose disease has lasted for 1-5 years had low testosterone level and their mean was 3.27+0.58 ng/ml while 74.1% of the patients with disease duration between 6-10 years had low testosterone levels and a mean of 2.23+0.78ng/ml. 83.3% of the patients with disease duration >10years had low testosterone levels and their mean level was 1.62+1.81ng/ml. Conclusion: Testosterone levels are low in type 2 diabetic men. These levels are further affected by age and duration of disease. Glycemic status had no statistically significant. Read more
Read More

Assessment of Hypogonadism in Men with Type 2 Diabetes Mellitus

Background: There is an established relationship between type 2 diabetes and Hypogonadism. Testosterone, the main gonadal steroid in men is lower in diabetic men when compared with healthy subjects. Currently, very few diabetic men with testosterone deficiency are diagnosed and treated worldwide. Knowledge of testosterone levels of patients will reveal those with androgen deficiency so that appropriate treatment will be offered. Objective: The aim of this study was to assess the prevalence of Hypogonadism based on biochemical measures of total testosterone deficiency in men with type 2 diabetes in Port Harcourt. Methods: Type 2 diabetic patients attending the Medical Out-Patient Clinic of University of Port Harcourt Teaching Hospital (UPTH) between April and May, 2012 were used for this study. Fasting blood sugar was measured using Randox kit, Testosterone was measured using Enzyme Linked Immunoassay. Data were analyzed using the SPSS package (Version 20.0.0). The mean levels of testosterone for the patients as a group and also according to age, glycemic state and duration of disease were computed. Values were expressed as a percentage of each group or as mean + 2SD. Comparisons between groups were made using the student t-test at 95% confidence interval. Results were significant if P < 0.05. Results: One hundred and forty two (142) patients were tested within the study period. 31.7% (45) of the 142 diabetic patients had a lower than normal testosterone level (Testosterone<3.0ng/ml). The mean testosterone levels decreased significantly in the older men (>70 years). The percentages of patients with low testosterone levels were increasingly higher as the age increased. 10.7% of patients aged 41-50 years had low testosterone levels. Their mean was 3.51+ 0.54 ng/ml. 12.8% of patients aged 51-60 years had low testosterone and their mean level was 3.35+0.58 ng/ml. 25.0% of the patients aged 61-70 years had low testosterone levels. Their mean was 2.89+0.68, while 92.3 of the patients >70 years had low testosterone with a mean of 1.57+0.70 ng/ml. The percentage of patients with low testosterone was not altered by the degree of rise in blood sugar level. 32.2% of the patients whose fasting blood glucose level were <10.0mmol/L had low testosterone levels and their mean was 2.99+0.83ng/ml while 28.0% of the patients with fasting blood glucose level >10mmol/L had low testosterone levels and their mean was 3.0+0.67 ng/ml. There was no significant difference between the two groups. 17.4% of the patients whose disease has lasted for 1-5 years had low testosterone level and their mean was 3.27+0.58 ng/ml while 74.1% of the patients with disease duration between 6-10 years had low testosterone levels and a mean of 2.23+0.78ng/ml. 83.3% of the patients with disease duration >10years had low testosterone levels and their mean level was 1.62+1.81ng/ml. Conclusion: Testosterone levels are low in type 2 diabetic men. These levels are further affected by age and duration of disease. Glycemic status had no statistically significant. Read more
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