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Increased Heart Rate and Steady State Among Sickle Cell Patients Seen in Sokoto, North-West Nigeria

July 31, 2021
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Ikedue et al

Greener Journal of Human Physiology and Anatomy

Vol. 3(1), pp. 01-10, 2021

ISSN: 2354-2314

Copyright ©2021, the copyright of this article is retained by the author(s)

https://gjournals.org/GJHPA

  

 

 

 

 

Increased Heart Rate and Steady State Among Sickle Cell Patients Seen in Sokoto, North-West Nigeria

 

 

1Michael I. Ikedue; 2Frank B.O. Mojiminiyi; 3Muhammad A. Ndakotsu; 4Simeon A. Isezuo; 5Adamu J. Bamaiyi

 

 

1MSc, Department of Physiology. Usmanu Danfodiyo University, Sokoto, Nigeria.

2PhD, Professor, Department of Physiology, Usmanu Danfodiyo University, Sokoto, Nigeria.

3MBBS, FMCPath, Associate Professor of Haematology and Consultant Haematologist Haematology Department, Usmanu Danfodiyo University, Sokoto, Nigeria.

4MBBS, FMCP, Professor of Medicine and Consultant Cardiologist, Internal Medicine Department, Usmanu Danfodiyo University, Sokoto, Nigeria.

5MBBS, PhD, Senior Lecturer, Department of Physiology, Usmanu Danfodiyo University, Sokoto, Nigeria.

 

 

ARTICLE INFO ABSTRACT
 

Article No.: 071021064

Type: Research

  

Background: Sickle cell anaemia (SCA) remains a major cause of morbidity and mortality among patients homozygous for the traits. However, some patients homozygous for the disease do not have vaso-occlusive crisis as much as others, and the reason for this is not yet clear.

Objectives: The present study aimed to assess haemodynamic and haematological parameters among adult SCA patients (with crisis or in steady state) attending clinics and compared same with normal adults.

Methods: One hundred and six consenting consecutive subjects were recruited under the groups; Steady (n = 53) or Crisis (n = 53) and compared the results with 40 apparently healthy genotype AA adults.

Results: We report that, the steady group, has significantly less Packed cell volume (PCV) compared to the normal group (27.39 ±4.36% Vs 33.44 ±1.80%, p <0.00005), but showed higher values of PCV compared to the crisis group (27.39 ±4.36% Vs 25.67 ± 4.23%, p <0.0422). The steady group compared to the crisis group, also demonstrated enhanced heart rate (HR) (84.19 ± 16.53 bpm Vs 78.96 ± 15.90 bpm, p = 0.019) and longer QTc (429.00 ± 37. 33 Vs 416.15 ±35.10, p = 0.0060).

Conclusions:  Enhanced HR, rate pressure product (RPP) and optimum systolic phase of the cardiac cycle (QTc) in the steady state sub-group, may result in better ventricular functions and cardiac output. Therefore, whole blood or intravenous fluid infusion in SCA patients may improve the chronotropic and inotropic properties of the heart, enhance tissue perfusion and oxygen delivery that will help reduce crisis in the patients.
 

Accepted:  15/07/2021

Published: 31/07/2021
 

*Corresponding Author

Dr Adamu Jibril Bamaiyi

E-mail: adamu,jibril @udusok.edu,ng; abamaiyi@ yahoo.com

Phone: +2348030925695
 

Keywords:

Sickle cell anaemia; Homozygous trait; Vaso-occlusive crisis; Steady state; Heart rate; Whole blood; Intravenous infusion; Cardiac output; Inotropic; Chronotropic
   

 

 

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Cite this Article: Ikedue MI; Mojiminiyi FBO; Ndakotsu MA; Isezuo SA; Bamaiyi AJ (2021). Increased Heart Rate and Steady State Among Sickle Cell Patients Seen in Sokoto, North-West Nigeria. Greener Journal of Human Physiology and Anatomy, 3(1): 1-10.

Journal Name : citation_journal : Greener Journal of Human Physiology and Anatomy

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