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Bioactive Principles Present in Aqueous Extracts of Oil Bean (Pentacletra macrophylla Benth) and their Effect in the Haematological and Biomedical Profile of Male Albino Wistar Rats

Oguwike et al

Greener Journal of Medical Sciences

Vol. 10(1), pp. 28-32, 2020

ISSN: 2276-7797

Copyright ©2020, the copyright of this article is retained by the author(s)

https://gjournals.org/GJMS  

 

 

 

 

 

Bioactive Principles Present in Aqueous Extracts of Oil Bean (Pentacletra macrophylla Benth) and their Effect in the Haematological and Biomedical Profile of Male Albino Wistar Rats

 

 

Oguwike F. N.1; Okafor I. J.2; Ifemeje J. C.3; Nwaka A.C.3; Offor C.C.4; Olisah M.C.4

 

 

  1. Department of Human Physiology, Faculty of Basic Medical Sciences, Chukwuemeka Odumegwu Ojukwu University Uli Campus, Anambra State.
  2. Department of Anatomy, Faculty of Basic Medical Sciences, Chukwuemeka Odumegwu Ojukwu University Uli Campus, Anmbra State.
  3. Department of Biochemistry, Faculty of Natural Sciences, Chukwuemeka Odumegwu Ojukwu University Uli Campus, Anambra State.
  4. Department of Medical Biochemistry, Faculty of Basic Medical Sciences, Chukwuemeka Odumegwu Ojukwu University Uli Campus, Anambra State.

 

 

ARTICLE INFO ABSTRACT  

Article No.: 062820081

Type: Research

   

The bioactive principles present in oil bean (Pentaclethra marophyllabenth) and their effects in the haematological and biochemical profile of male albino wistar rats were studied using 22 male albino wistar rats weighing 180–200g. The study is aimed at ascertaining the impact of prolonged administration of Pentaclethra macrophyllabenth on the haematological and biochemical profile of albino wistar rats. The 22 male albino rats were acclimatized in the animal house for 14 days. After this, they were divided into three groups (A, B, and C) respectively. Group A was the control group (6 rats), Group B (8 rats) on low dose of the extracts, while Group C (8 rats) on high dose of the extract. Group B and C received the extract for 28 days while Group A received normal rat feed and water ad libitum. Blood samples were collected from the animals by cardiac puncture and placed in E.D.T.A (Ethylene diamine tetracetic acid) and in plain tubes for the analysis. Results showed that Pentaclethra macrophyllabenth increased the haemoglobin concentration, packed cell volume, platelet count, and WBC count. It also caused elevation of the liver function profiles in the test rats due to prolonged administration. It could be deducted from this research that the extract of Pentaclethra macrophyllabenth contains some bioactive principles capable of altering the biochemical and haematological profile of rats.  

Accepted:  29/06/2020

Published: 31/07/2020  

*Corresponding Author

Prof. F.N Oguwike

E-mail: foguwike@gmail.com

Phone: 08037791363  

Keywords:

Bioactive; oil bean; haemoglobin; bilirubin; alanine; packed cell volume; platelet count; WBC count.    

 

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[Full Article – HTML]              [Full Article – EPUB]

 

 

REFERENCES

 

  1. Achinewhu S.C. (1982): Composition and food potential of African oil beans (Pentaclethra macrophylla)and bean (Mucuna pruriens). Journal of food science 47, p1736-1739.
  2. Brecher L and Cronkite M, (1950): Platelet count, in Dacie J.V ed, Basic Haematological Techniques, Practical Haematology, 6thedition. Churchill Livingstone, Edinburgh London, Melbourne,
  3.  Cugnani H.C and Ezenwanze E.C(1985): Antibacterial activity of extracts of ginger (Zingiber officinale)and African oil bean seed (Pentaclethra macrophylla). Journal of Communicable diseases 17:233-234
  4. Enujiugha V.N and Akanbi C.T(2005): Compositional changes in African oil bean seed (Pentaclethra macrophylla seed)during thermal processing. Pakistan Journal of nutrition 4(1) p27-30
  5.  Keay R.W.J, Onochie C.E.A and Standfield D.P(1969): Nigerian Trees. Department of Forest Research Ibadan p11,119-120
  6. Keay R.W.J, (1989). Trees of Nigeria, claredon press, oxford p256.
  7. Lorke D, (1973): A new approach to practical acute toxicity testing. Arch Toxicol 54:275-278
  8. Okafor J.C, (1982): Promising trees of agro forestry in southern Nigeria. In agro forestry in the African humid tropics Ed.L.H. MacDonald (proceeding a workshop held in Ibadan Nigeria 27thApril- 1st May 1981). Published by the United Nations University press Tokyo, Japan.
  9. Ikhuoria E.U, Aiwenegbe A.E and Okoli R (2006): Characteristics and composition of African oil bean seed (Pentaclethra macrophylla Benth). Chemtech Journal 3 p309-310
  10. Okorie C.C, Oparaocha E, Adewunmi C.O, Iwa E.O and Omodare S.K (2006): Antinoceptive, anti-inflammatory and cytotoxic activities of Pentaclethra macrophyllaaqueous extract in mice. African Journal of traditional, Complementary and Alternative medicine 3(1):44-53.
  11. Samuelson G, Faraha M.H, Percleeson E (1992): Investigation of plants used in traditional Medicine in Somalia. 11 plants of the families combretae labiates. Journal of Ethno pharmacology 37(1) 47-70.
  12. Sembulingham K, Sembuligan P (2010). Essential of Medical Physiology 5thed. P241-242.

 

 

Cite this Article: Oguwike FN; Okafor IJ; Ifemeje JC; Nwaka AC; Offor CC; Olisah MC (2020). Bioactive Principles Present in Aqueous Extracts of Oil Bean (Pentacletra macrophylla Benth) and their Effect in the Haematological and Biomedical Profile of Male Albino Wistar Rats. Greener Journal of Medical Sciences, 10(1): 28-32.

Journal Name : citation_journal : Greener Journal of  Medical Sciences

July 31, 2020
All articles, GJMS articles, Greener Journal of Medical Sciences

Bioactive Principles Present in Aqueous Extracts of Oil Bean (Pentacletra macrophylla Benth) and their Effect in the Haematological and Biomedical Profile of Male Albino Wistar Rats

Oguwike et al

Greener Journal of Medical Sciences

Vol. 10(1), pp. 28-32, 2020

ISSN: 2276-7797

Copyright ©2020, the copyright of this article is retained by the author(s)

https://gjournals.org/GJMS  

 

 

 

 

 

Bioactive Principles Present in Aqueous Extracts of Oil Bean (Pentacletra macrophylla Benth) and their Effect in the Haematological and Biomedical Profile of Male Albino Wistar Rats

 

 

Oguwike F. N.1; Okafor I. J.2; Ifemeje J. C.3; Nwaka A.C.3; Offor C.C.4; Olisah M.C.4

 

 

  1. Department of Human Physiology, Faculty of Basic Medical Sciences, Chukwuemeka Odumegwu Ojukwu University Uli Campus, Anambra State.
  2. Department of Anatomy, Faculty of Basic Medical Sciences, Chukwuemeka Odumegwu Ojukwu University Uli Campus, Anmbra State.
  3. Department of Biochemistry, Faculty of Natural Sciences, Chukwuemeka Odumegwu Ojukwu University Uli Campus, Anambra State.
  4. Department of Medical Biochemistry, Faculty of Basic Medical Sciences, Chukwuemeka Odumegwu Ojukwu University Uli Campus, Anambra State.

 

 

ARTICLE INFO ABSTRACT  

Article No.: 062820081

Type: Research

   

The bioactive principles present in oil bean (Pentaclethra marophyllabenth) and their effects in the haematological and biochemical profile of male albino wistar rats were studied using 22 male albino wistar rats weighing 180–200g. The study is aimed at ascertaining the impact of prolonged administration of Pentaclethra macrophyllabenth on the haematological and biochemical profile of albino wistar rats. The 22 male albino rats were acclimatized in the animal house for 14 days. After this, they were divided into three groups (A, B, and C) respectively. Group A was the control group (6 rats), Group B (8 rats) on low dose of the extracts, while Group C (8 rats) on high dose of the extract. Group B and C received the extract for 28 days while Group A received normal rat feed and water ad libitum. Blood samples were collected from the animals by cardiac puncture and placed in E.D.T.A (Ethylene diamine tetracetic acid) and in plain tubes for the analysis. Results showed that Pentaclethra macrophyllabenth increased the haemoglobin concentration, packed cell volume, platelet count, and WBC count. It also caused elevation of the liver function profiles in the test rats due to prolonged administration. It could be deducted from this research that the extract of Pentaclethra macrophyllabenth contains some bioactive principles capable of altering the biochemical and haematological profile of rats.  

Accepted:  29/06/2020

Published: 31/07/2020  

*Corresponding Author

Prof. F.N Oguwike

E-mail: foguwike@gmail.com

Phone: 08037791363  

Keywords:

Bioactive; oil bean; haemoglobin; bilirubin; alanine; packed cell volume; platelet count; WBC count.    

 

Return to Content       View[Full Article – PDF]

[Full Article – HTML]              [Full Article – EPUB]

 

 

REFERENCES

 

  1. Achinewhu S.C. (1982): Composition and food potential of African oil beans (Pentaclethra macrophylla)and bean (Mucuna pruriens). Journal of food science 47, p1736-1739.
  2. Brecher L and Cronkite M, (1950): Platelet count, in Dacie J.V ed, Basic Haematological Techniques, Practical Haematology, 6thedition. Churchill Livingstone, Edinburgh London, Melbourne,
  3.  Cugnani H.C and Ezenwanze E.C(1985): Antibacterial activity of extracts of ginger (Zingiber officinale)and African oil bean seed (Pentaclethra macrophylla). Journal of Communicable diseases 17:233-234
  4. Enujiugha V.N and Akanbi C.T(2005): Compositional changes in African oil bean seed (Pentaclethra macrophylla seed)during thermal processing. Pakistan Journal of nutrition 4(1) p27-30
  5.  Keay R.W.J, Onochie C.E.A and Standfield D.P(1969): Nigerian Trees. Department of Forest Research Ibadan p11,119-120
  6. Keay R.W.J, (1989). Trees of Nigeria, claredon press, oxford p256.
  7. Lorke D, (1973): A new approach to practical acute toxicity testing. Arch Toxicol 54:275-278
  8. Okafor J.C, (1982): Promising trees of agro forestry in southern Nigeria. In agro forestry in the African humid tropics Ed.L.H. MacDonald (proceeding a workshop held in Ibadan Nigeria 27thApril- 1st May 1981). Published by the United Nations University press Tokyo, Japan.
  9. Ikhuoria E.U, Aiwenegbe A.E and Okoli R (2006): Characteristics and composition of African oil bean seed (Pentaclethra macrophylla Benth). Chemtech Journal 3 p309-310
  10. Okorie C.C, Oparaocha E, Adewunmi C.O, Iwa E.O and Omodare S.K (2006): Antinoceptive, anti-inflammatory and cytotoxic activities of Pentaclethra macrophyllaaqueous extract in mice. African Journal of traditional, Complementary and Alternative medicine 3(1):44-53.
  11. Samuelson G, Faraha M.H, Percleeson E (1992): Investigation of plants used in traditional Medicine in Somalia. 11 plants of the families combretae labiates. Journal of Ethno pharmacology 37(1) 47-70.
  12. Sembulingham K, Sembuligan P (2010). Essential of Medical Physiology 5thed. P241-242.

 

 

Cite this Article: Oguwike FN; Okafor IJ; Ifemeje JC; Nwaka AC; Offor CC; Olisah MC (2020). Bioactive Principles Present in Aqueous Extracts of Oil Bean (Pentacletra macrophylla Benth) and their Effect in the Haematological and Biomedical Profile of Male Albino Wistar Rats. Greener Journal of Medical Sciences, 10(1): 28-32.

Journal Name : citation_journal : Greener Journal of  Medical Sciences

July 31, 2020
All articles, GJMS articles, Greener Journal of Medical Sciences

Bioactive Principles Present in Aqueous Extracts of Oil Bean (Pentacletra macrophylla Benth) and their Effect in the Haematological and Biomedical Profile of Male Albino Wistar Rats

Oguwike et al

Greener Journal of Medical Sciences

Vol. 10(1), pp. 28-32, 2020

ISSN: 2276-7797

Copyright ©2020, the copyright of this article is retained by the author(s)

https://gjournals.org/GJMS  

 

 

 

 

 

Bioactive Principles Present in Aqueous Extracts of Oil Bean (Pentacletra macrophylla Benth) and their Effect in the Haematological and Biomedical Profile of Male Albino Wistar Rats

 

 

Oguwike F. N.1; Okafor I. J.2; Ifemeje J. C.3; Nwaka A.C.3; Offor C.C.4; Olisah M.C.4

 

 

  1. Department of Human Physiology, Faculty of Basic Medical Sciences, Chukwuemeka Odumegwu Ojukwu University Uli Campus, Anambra State.
  2. Department of Anatomy, Faculty of Basic Medical Sciences, Chukwuemeka Odumegwu Ojukwu University Uli Campus, Anmbra State.
  3. Department of Biochemistry, Faculty of Natural Sciences, Chukwuemeka Odumegwu Ojukwu University Uli Campus, Anambra State.
  4. Department of Medical Biochemistry, Faculty of Basic Medical Sciences, Chukwuemeka Odumegwu Ojukwu University Uli Campus, Anambra State.

 

 

ARTICLE INFO ABSTRACT  

Article No.: 062820081

Type: Research

   

The bioactive principles present in oil bean (Pentaclethra marophyllabenth) and their effects in the haematological and biochemical profile of male albino wistar rats were studied using 22 male albino wistar rats weighing 180–200g. The study is aimed at ascertaining the impact of prolonged administration of Pentaclethra macrophyllabenth on the haematological and biochemical profile of albino wistar rats. The 22 male albino rats were acclimatized in the animal house for 14 days. After this, they were divided into three groups (A, B, and C) respectively. Group A was the control group (6 rats), Group B (8 rats) on low dose of the extracts, while Group C (8 rats) on high dose of the extract. Group B and C received the extract for 28 days while Group A received normal rat feed and water ad libitum. Blood samples were collected from the animals by cardiac puncture and placed in E.D.T.A (Ethylene diamine tetracetic acid) and in plain tubes for the analysis. Results showed that Pentaclethra macrophyllabenth increased the haemoglobin concentration, packed cell volume, platelet count, and WBC count. It also caused elevation of the liver function profiles in the test rats due to prolonged administration. It could be deducted from this research that the extract of Pentaclethra macrophyllabenth contains some bioactive principles capable of altering the biochemical and haematological profile of rats.  

Accepted:  29/06/2020

Published: 31/07/2020  

*Corresponding Author

Prof. F.N Oguwike

E-mail: foguwike@gmail.com

Phone: 08037791363  

Keywords:

Bioactive; oil bean; haemoglobin; bilirubin; alanine; packed cell volume; platelet count; WBC count.    

 

Return to Content       View[Full Article – PDF]

[Full Article – HTML]              [Full Article – EPUB]

 

 

REFERENCES

 

  1. Achinewhu S.C. (1982): Composition and food potential of African oil beans (Pentaclethra macrophylla)and bean (Mucuna pruriens). Journal of food science 47, p1736-1739.
  2. Brecher L and Cronkite M, (1950): Platelet count, in Dacie J.V ed, Basic Haematological Techniques, Practical Haematology, 6thedition. Churchill Livingstone, Edinburgh London, Melbourne,
  3.  Cugnani H.C and Ezenwanze E.C(1985): Antibacterial activity of extracts of ginger (Zingiber officinale)and African oil bean seed (Pentaclethra macrophylla). Journal of Communicable diseases 17:233-234
  4. Enujiugha V.N and Akanbi C.T(2005): Compositional changes in African oil bean seed (Pentaclethra macrophylla seed)during thermal processing. Pakistan Journal of nutrition 4(1) p27-30
  5.  Keay R.W.J, Onochie C.E.A and Standfield D.P(1969): Nigerian Trees. Department of Forest Research Ibadan p11,119-120
  6. Keay R.W.J, (1989). Trees of Nigeria, claredon press, oxford p256.
  7. Lorke D, (1973): A new approach to practical acute toxicity testing. Arch Toxicol 54:275-278
  8. Okafor J.C, (1982): Promising trees of agro forestry in southern Nigeria. In agro forestry in the African humid tropics Ed.L.H. MacDonald (proceeding a workshop held in Ibadan Nigeria 27thApril- 1st May 1981). Published by the United Nations University press Tokyo, Japan.
  9. Ikhuoria E.U, Aiwenegbe A.E and Okoli R (2006): Characteristics and composition of African oil bean seed (Pentaclethra macrophylla Benth). Chemtech Journal 3 p309-310
  10. Okorie C.C, Oparaocha E, Adewunmi C.O, Iwa E.O and Omodare S.K (2006): Antinoceptive, anti-inflammatory and cytotoxic activities of Pentaclethra macrophyllaaqueous extract in mice. African Journal of traditional, Complementary and Alternative medicine 3(1):44-53.
  11. Samuelson G, Faraha M.H, Percleeson E (1992): Investigation of plants used in traditional Medicine in Somalia. 11 plants of the families combretae labiates. Journal of Ethno pharmacology 37(1) 47-70.
  12. Sembulingham K, Sembuligan P (2010). Essential of Medical Physiology 5thed. P241-242.

 

 

Cite this Article: Oguwike FN; Okafor IJ; Ifemeje JC; Nwaka AC; Offor CC; Olisah MC (2020). Bioactive Principles Present in Aqueous Extracts of Oil Bean (Pentacletra macrophylla Benth) and their Effect in the Haematological and Biomedical Profile of Male Albino Wistar Rats. Greener Journal of Medical Sciences, 10(1): 28-32.

Journal Name : citation_journal : Greener Journal of  Medical Sciences

July 31, 2020
All articles, GJMS articles, Greener Journal of Medical Sciences

Bioactive Principles Present in Aqueous Extracts of Oil Bean (Pentacletra macrophylla Benth) and their Effect in the Haematological and Biomedical Profile of Male Albino Wistar Rats

Oguwike et al

Greener Journal of Medical Sciences

Vol. 10(1), pp. 28-32, 2020

ISSN: 2276-7797

Copyright ©2020, the copyright of this article is retained by the author(s)

https://gjournals.org/GJMS  

 

 

 

 

 

Bioactive Principles Present in Aqueous Extracts of Oil Bean (Pentacletra macrophylla Benth) and their Effect in the Haematological and Biomedical Profile of Male Albino Wistar Rats

 

 

Oguwike F. N.1; Okafor I. J.2; Ifemeje J. C.3; Nwaka A.C.3; Offor C.C.4; Olisah M.C.4

 

 

  1. Department of Human Physiology, Faculty of Basic Medical Sciences, Chukwuemeka Odumegwu Ojukwu University Uli Campus, Anambra State.
  2. Department of Anatomy, Faculty of Basic Medical Sciences, Chukwuemeka Odumegwu Ojukwu University Uli Campus, Anmbra State.
  3. Department of Biochemistry, Faculty of Natural Sciences, Chukwuemeka Odumegwu Ojukwu University Uli Campus, Anambra State.
  4. Department of Medical Biochemistry, Faculty of Basic Medical Sciences, Chukwuemeka Odumegwu Ojukwu University Uli Campus, Anambra State.

 

 

ARTICLE INFO ABSTRACT  

Article No.: 062820081

Type: Research

   

The bioactive principles present in oil bean (Pentaclethra marophyllabenth) and their effects in the haematological and biochemical profile of male albino wistar rats were studied using 22 male albino wistar rats weighing 180–200g. The study is aimed at ascertaining the impact of prolonged administration of Pentaclethra macrophyllabenth on the haematological and biochemical profile of albino wistar rats. The 22 male albino rats were acclimatized in the animal house for 14 days. After this, they were divided into three groups (A, B, and C) respectively. Group A was the control group (6 rats), Group B (8 rats) on low dose of the extracts, while Group C (8 rats) on high dose of the extract. Group B and C received the extract for 28 days while Group A received normal rat feed and water ad libitum. Blood samples were collected from the animals by cardiac puncture and placed in E.D.T.A (Ethylene diamine tetracetic acid) and in plain tubes for the analysis. Results showed that Pentaclethra macrophyllabenth increased the haemoglobin concentration, packed cell volume, platelet count, and WBC count. It also caused elevation of the liver function profiles in the test rats due to prolonged administration. It could be deducted from this research that the extract of Pentaclethra macrophyllabenth contains some bioactive principles capable of altering the biochemical and haematological profile of rats.  

Accepted:  29/06/2020

Published: 31/07/2020  

*Corresponding Author

Prof. F.N Oguwike

E-mail: foguwike@gmail.com

Phone: 08037791363  

Keywords:

Bioactive; oil bean; haemoglobin; bilirubin; alanine; packed cell volume; platelet count; WBC count.    

 

Return to Content       View[Full Article – PDF]

[Full Article – HTML]              [Full Article – EPUB]

 

 

REFERENCES

 

  1. Achinewhu S.C. (1982): Composition and food potential of African oil beans (Pentaclethra macrophylla)and bean (Mucuna pruriens). Journal of food science 47, p1736-1739.
  2. Brecher L and Cronkite M, (1950): Platelet count, in Dacie J.V ed, Basic Haematological Techniques, Practical Haematology, 6thedition. Churchill Livingstone, Edinburgh London, Melbourne,
  3.  Cugnani H.C and Ezenwanze E.C(1985): Antibacterial activity of extracts of ginger (Zingiber officinale)and African oil bean seed (Pentaclethra macrophylla). Journal of Communicable diseases 17:233-234
  4. Enujiugha V.N and Akanbi C.T(2005): Compositional changes in African oil bean seed (Pentaclethra macrophylla seed)during thermal processing. Pakistan Journal of nutrition 4(1) p27-30
  5.  Keay R.W.J, Onochie C.E.A and Standfield D.P(1969): Nigerian Trees. Department of Forest Research Ibadan p11,119-120
  6. Keay R.W.J, (1989). Trees of Nigeria, claredon press, oxford p256.
  7. Lorke D, (1973): A new approach to practical acute toxicity testing. Arch Toxicol 54:275-278
  8. Okafor J.C, (1982): Promising trees of agro forestry in southern Nigeria. In agro forestry in the African humid tropics Ed.L.H. MacDonald (proceeding a workshop held in Ibadan Nigeria 27thApril- 1st May 1981). Published by the United Nations University press Tokyo, Japan.
  9. Ikhuoria E.U, Aiwenegbe A.E and Okoli R (2006): Characteristics and composition of African oil bean seed (Pentaclethra macrophylla Benth). Chemtech Journal 3 p309-310
  10. Okorie C.C, Oparaocha E, Adewunmi C.O, Iwa E.O and Omodare S.K (2006): Antinoceptive, anti-inflammatory and cytotoxic activities of Pentaclethra macrophyllaaqueous extract in mice. African Journal of traditional, Complementary and Alternative medicine 3(1):44-53.
  11. Samuelson G, Faraha M.H, Percleeson E (1992): Investigation of plants used in traditional Medicine in Somalia. 11 plants of the families combretae labiates. Journal of Ethno pharmacology 37(1) 47-70.
  12. Sembulingham K, Sembuligan P (2010). Essential of Medical Physiology 5thed. P241-242.

 

 

Cite this Article: Oguwike FN; Okafor IJ; Ifemeje JC; Nwaka AC; Offor CC; Olisah MC (2020). Bioactive Principles Present in Aqueous Extracts of Oil Bean (Pentacletra macrophylla Benth) and their Effect in the Haematological and Biomedical Profile of Male Albino Wistar Rats. Greener Journal of Medical Sciences, 10(1): 28-32.

Journal Name : citation_journal : Greener Journal of  Medical Sciences

July 31, 2020